Numerous studies suggest that alcohol exposure during adolescence results in persistent detrimental effects on brain, with the prefrontal brain regions being particularly vulnerable. Using resting-state fMRI, the projects outlined in this mentored K01 award will characterize the development of frontal brain connectivity in rats and investigate how brain connectivity may be altered after adolescent alcohol exposure. Ultimately, these studies can be informative for our understanding of the consequences of adolescent alcohol exposure and will help guide future research dedicated to prevention and reversal of these negative effects.
